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The Engineering Angle on Everyday Joint Pain
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Research & Sources
- Lubricin / PRG4 and boundary lubrication: Waller KA et al., PNAS (2013); Jay GD, Matrix Biology (2014); Reesink HL et al., Arthritis Research & Therapy (2016).
- Hyaluronic acid in joint lubrication: Lin W & Klein J, Acta Biomaterialia (2020); Liu Y et al., ACS Applied Materials & Interfaces (2020).
- Inflammation & cytokines in osteoarthritis: Goldring MB & Otero M, Current Opinion in Rheumatology (2011); Goldring MB, Arthritis Research & Therapy (2004); De Roover A et al., Osteoarthritis & Cartilage (2023).
- Microgravity and cartilage/joint health: Ganse B et al., NPJ Microgravity (2022); Fitzgerald J, NPJ Microgravity (2017); ISS National Lab release (2024).
- Synovial joint biomechanics (overview): StatPearls (2024); textbook chapter overview.
- Global epidemiology & burden of osteoarthritis: Hunter DJ & Bierma-Zeinstra S, The Lancet (2019).
- Osteoarthritis pathogenesis (primer): Loeser RF et al., Nature Reviews Disease Primers (2016).
- Articular cartilage structure & function: Sophia Fox AJ et al., Sports Health (2009).
- Aging of articular cartilage: Buckwalter JA & Mankin HJ, Journal of Bone & Joint Surgery (1997).
- Clinical review, knee OA: Felson DT, New England Journal of Medicine (2006).
- OARSI management recommendations: Zhang W et al., Osteoarthritis & Cartilage (2008/2010 updates).